American Journal of Infectious Diseases

Determination of the Salivary Anti-Phenolic Glycolipid-1 Antibody in Leprosy Patients as a Tool to Monitoring Multidrugtherapy

N. L.B. Bonfitto, A. C.F. Motta, R. B. Furini, M. C. Komesu, M. M.P. Do Nascimento, J. F.C. Figueiredo and N. T. Foss

DOI : 10.3844/ajidsp.2009.314.319

American Journal of Infectious Diseases

Volume 5, Issue 4

Pages 314-319

Abstract

Problem statement: The upper airways has a great importance as a route of M. leprae infection and because of the possibility of identifying relevant tools by systematic patient evaluation, the detection of leprosy patients by means of salivary markers becomes important. The aim of this study was to analyze anti-phenolic glycolipid 1 (anti-PGL-1) salivary and serum titers as parameters for correlation with infection, antigen exposure and treatment response. Approach: Leprosy patients before, during and after specific treatment for leprosy were selected. Salivary and serum anti-PGL-1 levels were determined by Enzyme-Linked Immunosorbent Assay (ELISA) in 30 leprosy patients ranging in age from 17-71 years old (mean: 48.45

Copyright

© 2009 N. L.B. Bonfitto, A. C.F. Motta, R. B. Furini, M. C. Komesu, M. M.P. Do Nascimento, J. F.C. Figueiredo and N. T. Foss. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.