@article {10.3844/ajavsp.2006.8.12,
article_type = {journal},
title = {Inefficacy of Topical Diclofenac in Arthritic Horses},
author = {Villarino, Nicolás F. and Vispo, Tomas J. and Marcos, and Ferrante, and Landoni, María F.},
volume = {1},
number = {1},
year = {2006},
month = {Jun},
pages = {8-12},
doi = {10.3844/ajavsp.2006.8.12},
url = {https://thescipub.com/abstract/ajavsp.2006.8.12},
abstract = {The objective of the present study was test the anti-inflammatory efficacy of diclofenac dietilamine, applied epicutaneously at a dose rate of 0.44 mg kg-1, in a model of acute arthritis in horses. Four clinical end-points, as well as two biochemical markers, were used as surrogate markers of the required clinical response (analgesia, anti-inflammatory). Low diclofenac concentrations were measured in blood (Cmax 0.04±0.03 ug mL-1) and synovial fluid (Cmax 0.08 ±0.08 ug mL-1) from the first to the last sampling time. The statistical comparison of the clinical end-points and biochemical markers between placebo and dicilofenac treated group indicated a lack of pharmacological effect of this compound after epicutaneous administration.},
journal = {American Journal of Animal and Veterinary Sciences},
publisher = {Science Publications}
}