TY  - JOUR
AU  - Villarino, Nicolás F. 
AU  - Vispo, Tomas J. 
AU  - Marcos, 
AU  - Ferrante, 
AU  - Landoni, María F. 
PY  - 2006
TI  - Inefficacy of Topical Diclofenac in Arthritic Horses
JF  - American Journal of Animal and Veterinary Sciences
VL  - 1
IS  - 1
DO  - 10.3844/ajavsp.2006.8.12
UR  - https://thescipub.com/abstract/ajavsp.2006.8.12
AB  - The objective of the present study was test the anti-inflammatory efficacy of diclofenac dietilamine, applied epicutaneously at a dose rate of 0.44 mg kg-1, in a model of acute arthritis in horses. Four clinical end-points, as well as two biochemical markers, were used as surrogate markers of the required clinical response (analgesia, anti-inflammatory). Low diclofenac concentrations were measured in blood (Cmax 0.04±0.03 ug mL-1) and synovial fluid (Cmax 0.08 ±0.08 ug mL-1) from the first to the last sampling time. The statistical comparison of the clinical end-points and biochemical markers between placebo and dicilofenac treated group indicated a lack of pharmacological effect of this compound after epicutaneous administration.