TY  - JOUR
AU  - Manizheh, Sayyah-Melli 
AU  - Maryamalsadat, Kazemi-Shishvan 
AU  - Jafar, Solaimani-Rad 
AU  - Mohammad-Reza, Rashidi 
AU  - Leila, Roshangar 
AU  - Nadereh, Rashtchizadeh 
AU  - Elaheh, Ouladesahebmadarek 
AU  - Morteza, Ghojazadeh 
AU  - Omid, Mashrabi 
PY  - 2011
TI  - The Ovario-Protective Effect of Erythropoietin against Oxidative Damage Associated with Reperfusion Following Ovarian Torsion in Rat
JF  - American Journal of Animal and Veterinary Sciences
VL  - 6
IS  - 1
DO  - 10.3844/ajavsp.2011.18.24
UR  - https://thescipub.com/abstract/ajavsp.2011.18.24
AB  - Problem statement: To show the effect of recombinant Erythropoietin (rhEPO) on the
ovarian viability and histology in the twisted ischemic ovaries in rats, followed by detorsion.
Approach: An experimental study was conducted in primate clinic of the School of Medicine, Tabriz
University of Medical Sciences from Dec. 2008 to Apr. 2009. Forty, 4 month old Wistar rats are cased
in the present study divided into 4 groups. Ovarian ischemia was performed by torsion which was kept
stable by using a vascular microclip for 4 h. In group 1, the ovary were surgically removed, fixed and
analyzed histochemically. In group 2, the same procedure was repeated after 3 h reperfusion. In the
next two groups, the same was performed rhEPO was administrated 400 u kg−1 1 h after torsion of the
ovaries. Results: Thirty-two out of 40 rats were followed. There was a significant difference between
groups in the levels of Malondialdehyde (MDA), Total Antioxidants (TA), Superoxidase (SOD), Nitric
Oxide (NO) glutathione ( p