@article {10.3844/ajptsp.2007.4.9, article_type = {journal}, title = {The Effect of Vitamin C on the Metabolic Parameters of Experimental Diabetes Mellitus}, author = {Al-Shamsi, Mariam and Amin, Amr and Adeghate, Ernest}, volume = {2}, year = {2007}, month = {Mar}, pages = {4-9}, doi = {10.3844/ajptsp.2007.4.9}, url = {https://thescipub.com/abstract/ajptsp.2007.4.9}, abstract = {The role of vitamin C on diabetes mellitus is unknown. The purpose of this study was to examine the effect of oral administration of vitamin C on some of the metabolic parameters of diabetic rats. Diabetes was induced by intraperitoneal injection of STZ (60 mg kgˉ1 body weight at 12 weeks of age). Vitamin C (10, 50, 100 mg kgˉ1 body weight) was administered orally for a period of four weeks to normal and diabetic male Wistar rats. In some experiments vitamin C was given either before or after the induction of diabetes mellitus. Glucose tolerance test (GTT) was performed on fasted normal, diabetic and vitamin C-treated rats at the end of the experimental period. Blood sugar level and weight were also recorded on a weekly basis for each rat in different groups. Vitamin C significantly (p}, journal = {American Journal of Pharmacology and Toxicology}, publisher = {Science Publications} }