@article {10.3844/ajptsp.2011.59.67,
article_type = {journal},
title = {Effects of Melatonin in Prevention of Neuropathy in STZ-Induced Diabetic Rats},
author = {Zangiabadi, Nasser and Sheibani, Vahid and Asadi-Shekaari, Majid and Shabani, Mohammad and Jafari, Mandana and Asadi, Ali Reza and Tajadini, Haleh and Jarahi, Morteza},
volume = {6},
year = {2011},
month = {Sep},
pages = {59-67},
doi = {10.3844/ajptsp.2011.59.67},
url = {https://thescipub.com/abstract/ajptsp.2011.59.67},
abstract = {Problem statement: Diabetes mellitus occurs mainly with chronic polyneuropathy, and oxidative stress plays an important role in emergence of most neurologic and behavioral changes in diabetic patients. Many studies have focused on the beneficial effects of various antioxidants such as melatonin on diabetic neuropathy. The aim of this study is to evaluate the effect of melatonin in prevention of neuropathy in Streptozotocin-induced diabetic rats. After prescribing Streptozotocin (STZ), treatment rats received melatonin (10 mg kg day-1) or DMSO for a period of 6 weeks. Approach: At the end of the sixth week, non diabetic control group, diabetic control group (sham) and treated rats were examined by thermal pain response tests (hot plate and tail flick). The horizontal and vertical activities of rats were measured in an open field test. After that, Motor Nerve Conduction Velocity (MNCV) of sciatic-tibial nerve recorded. Also, to study morphological alterations resulting from diabetic neuropathy of sciatic nerve, Myelinated Fiber Diameter (MFD), Axon Diameter (AD) and Myelin Sheath Diameter (MSD) were evaluated by light microscope. Results: According to hot plate results, response time to thermal pain at the end of sixth week in sham group showed a significant decrease in comparison with the control group (p},
journal = {American Journal of Pharmacology and Toxicology},
publisher = {Science Publications}
}