TY  - JOUR
AU  - Bello, Yanes Brum 
AU  - De Almeida, Alexandre Cossenza Pettezzoni 
AU  - Sueth, Daniela Mendonca 
AU  - Belizario, Eduardo Carvalho 
AU  - Brandao, Fabiola Sampaio 
AU  - Leite, Marco Araujo 
AU  - Orsini, Marco 
AU  - Silva Catharino, Antonio Marcos Da 
PY  - 2014
TI  - PROBABLE CREUTZFELDT JAKOB DISEASE: CASE REPORT
JF  - Current Research in Medicine
VL  - 5
IS  - 1
DO  - 10.3844/amjsp.2014.13.15
UR  - https://thescipub.com/abstract/amjsp.2014.13.15
AB  - Prion diseases are associated with the accumulation of an abnormal isoformof cellular prion protein (PrPSc), which is the principal constituent of prions. Prions replicate in lymphoreticular tissues before neuroinvasion, suggesting that lymphoreticular biopsy samples may allow early diagnosis by detection of PrPSc. Creutzfeldt-Jakob Disease (CJD) is the most frequent prion disease in humans. Clinical diagnosis of sporadic (CJD) is based on the evaluation of rapidly progressive dementia, ataxia, myoclonus, changes on the electroencephalogram and other neurological signs. We report a problable (CJD) case in Santa Barbara surgical center, Rio de Janeiro, Brazil. From our clinical case, we decided to do a brief review about (CJD) researching at MedLine and Pubmed, using terms Creutzfeldt-Jakob disease and Prion diseases. A definite diagnosis, however, is confined to cases that have been evaluated neuropathlogically or by equivalent diagnostic techniques. The range in clinical expression of the disease is better appreciated and the existence of &#34atypical&#34 cases of CJD is increasingly recognized. The clinical characteristics, laboratory findings, differential diagnosis, mechanisms of transmission and the actual therapeutic approach are discussed.