American Journal of Pharmacology and Toxicology

Spirulina protects against cadmium-induced hepatotoxicity in rats

Amr Amin, Alaaeldin A. Hamza, Sayel Daoud and Waleed Hamza

DOI : 10.3844/ajptsp.2006.21.25

American Journal of Pharmacology and Toxicology

Volume 1, Issue 2

Pages 21-25


Cadmium (Cd) is an environmental and industrial cumulative pollutant that most affects many organs specially the liver. The protective effect of Spirulina, filamentous blue green algae, on Cd – induced oxidative stress and hepatotoxicity was evaluated in male rats. Oral administration of water extract of Spirulina for seven days followed by an acute toxic dose of Cd (3.5 mg kg b.wt.-1), reduced the hepatotoxicity and attenuated the Cd-induced oxidative stress. Spirulina treatment showed marked reduction in serum aminotrasferase activities and elevation in lipid peroxidation and recovery of the endogenous levels of antioxidants following Cd-intoxication. The Cd-induced hepatic histopathological changes were also minimized with the tested extract. These results suggest that Spirulina algae might play a role in reducing the toxic effect of Cd and its antioxidant properties seems to mediate such a protective effect.


© 2006 Amr Amin, Alaaeldin A. Hamza, Sayel Daoud and Waleed Hamza. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.