Research Article Open Access

Utility of Certain Π Acceptors for Spectrophotometric Determination of Sildenafil Citrate

Nora H. Al-Shaalan

Abstract

Sildenafil citrate was determined through charge transfer complexes (CTC) formation with three electron acceptor reagents. The methods involve the reaction of Sildenafil citrate as n-donor with either Chloranil (tetrachloro 1,4-benzoquinone), tetracyanoethylene (TCNE) or 7,7,8,8-tetracyanoquinodimethane (TCNQ) as n-acceptors, to give a stable and highly colored radical anion. The colored products were quantified spectrophotometrically. The condition ranges adhering to Beer's law are 0.05-3.00 mg/ml. The molar ratios of the reactants were ascertained. The different parameters were carefully studied and optimized. Statistical analysis of the results revealed equal precision and accuracy to the results of the reported method. The methods were applied for determination of sildenafil citrate in pure form and in Viagra tablets.

American Journal of Applied Sciences
Volume 4 No. 10, 2007, 746-750

DOI: https://doi.org/10.3844/ajassp.2007.746.750

Submitted On: 7 April 2007 Published On: 31 October 2007

How to Cite: Al-Shaalan, N. H. (2007). Utility of Certain Π Acceptors for Spectrophotometric Determination of Sildenafil Citrate. American Journal of Applied Sciences, 4(10), 746-750. https://doi.org/10.3844/ajassp.2007.746.750

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Keywords

  • Distributed system
  • replication
  • consistency
  • synchronous
  • transaction
  • serializability