Research Article Open Access

Ginger Supplementation Enhances Working Memory of the Post-Menopause Women

Naritsara Saenghong1, Jintanaporn Wattanathorn2, Terdthai Tong-Un2, Supaporn Muchimapura2, Nawanant Piyavhatkul3, Chuleratana Bunchonglikitkul4 and Tanwarat Kajsongkram4
  • 1 Department of Physiology, (Neuroscience Program) and Graduate School, Faculty of Medicine, Khon Kaen University, 40002, Thailand
  • 2 Integrative Complimentary Alternative Medicine Research Group, Thailand
  • 3 Department of Psychiatry, Faculty of Medicine, Khon Kaen University, 40002, Thailand
  • 4 Thailand Institute of Scientific and Technological Research, Pathumthani, 12120, Thailand


Problem statement: Cognitive impairment is one important problem in post-menopausal women. Although hormone therapy can improve this condition, it also produces adverse effect. Recent findings showed that this condition could be mitigated by the herb. Ginger or Zingiber officinale Roscoe, a plant in a family of Zingiberaceae, was previously demonstrated the neuroprotection and cognitive enhancing effects. Therefore, this study was set up to determine whether ginger rhizome extract could improve attention and working memory of the post-menopausal women. Approach: Sixty healthy post-menopausal women were randomly assigned to receive either placebo or standardized plant extract at doses of 400 and 800 mg once daily for 3 months. After the assessment of biographic information, they were evaluated the working memory and cognitive function using computerized battery test and the auditory oddball paradigm of event related potential before and after 3-month of intervention. Results: The ginger treated group decreased N100 and P300 latencies but increased N100 and P300 amplitudes in accompany with the enhanced working memory including the power of attention, continuity of attention, speed and quality of memory. Conclusion: Our results suggested that ginger is the potential cognitive enhancer for post-menopausal women. However, further researches are still required.

American Journal of Applied Sciences
Volume 8 No. 12, 2011, 1241-1248


Submitted On: 20 August 2011 Published On: 10 October 2011

How to Cite: Saenghong, N., Wattanathorn, J., Tong-Un, T., Muchimapura, S., Piyavhatkul, N., Bunchonglikitkul, C. & Kajsongkram, T. (2011). Ginger Supplementation Enhances Working Memory of the Post-Menopause Women. American Journal of Applied Sciences, 8(12), 1241-1248.

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  • Ginger rhizome
  • Zingiber officinale
  • attention impairment
  • working memory
  • post-menopausal women
  • computerized battery
  • ginger extract
  • intellectual function