Research Article Open Access

Mulberry Fruits Protects Against Age-Related Cognitive Decline

Jintanaporn Wattanathorn1, Supaporn Muchimapura2, Wipawee Thukhammee2, Terdthai Tong-un2, Panakporn Wannanon2, Nattaporn Phunchago3, Pratchaya Kaewkaen3, Thanes Chantes4, Wiroje Kaewruang4, Suttisan Pimpasalee4 and Sathaporn Wongareonwanakij1
  • 1 Integrative Complementary Alternative Medicine Research Center, Khon Kaen University, Khon Kaen, Thailand
  • 2 Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
  • 3 Department of Physiology (Neuroscience Program), Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
  • 4 Department of Sericulture, The Queen Sirikit Ministry of Agriculture and Cooperatives, Thailand


Problem statement: The phenolic compounds and anthocyanin contents, the antioxidant and Acetylcholinesterase Inhibitor (AChI) activities of mulberry fruits were determined. Approach: Analysis of phenolic compounds and anthocyanin were performed using Folin Ciocalteu reagent and pH-differential method respectively. The antioxidant activity was determined using DPPH and FRAP assays while AChI activity was determined using Ellman method. Results: The mulberry fruit powder contained high amount of phenolic compounds and anthocyanin, It also exhibited strong antioxidant and AChEI activities. Based on the beneficial effect of polyphenol compounds and anthocyanin on brain, we also further evaluated the neuroprotective and cognitive enhancing effects of mulberry fruits in animal model of age-related cognitive decline. Surprisingly mulberry fruits could mitigate brain damage and memory impairment in age-related cognitive decline. The possible mechanism might be associated with its antioxidant and AChEI activities. Conclusion: In conclusion, Mulberry fruits are the potential neuroprotectant and cognitive enhancer. However, further investigations are required.

American Journal of Applied Sciences
Volume 9 No. 9, 2012, 1503-1511


Submitted On: 8 March 2012 Published On: 8 August 2012

How to Cite: Wattanathorn, J., Muchimapura, S., Thukhammee, W., Tong-un, T., Wannanon, P., Phunchago, N., Kaewkaen, P., Chantes, T., Kaewruang, W., Pimpasalee, S. & Wongareonwanakij, S. (2012). Mulberry Fruits Protects Against Age-Related Cognitive Decline. American Journal of Applied Sciences, 9(9), 1503-1511.

  • 16 Citations



  • Mulberry fruit
  • hippocampal damage
  • memory impairment
  • Senescence-Accelerated Mice (SAMP)
  • Gallic Acid Equivalents (GAE)
  • Fresh Weight (FW)