Research Article Open Access

Potential Cancer Chemopreventive Activity of Styryllactones from Goniothalamus marcanii

Chalong Mahiwan1, Mongkol Buayairaksa2, Narong Nuntasaen3, Puttinan Meepowpan4 and Wilart Pompimon1
  • 1 Laboratory of Natural Products, Center of Excellence for Innovation in Chemistry, Faculty of Science, Lampang Rajabhat University, Lampang 52100, Thailand
  • 2 Department of Chemistry, Center of Excellence for Innovation in Chemistry, Natural Products Research Unit, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand
  • 3 Department of National Park, Forest Herbarium, Wildlife and Plant Conservation, Ministry of Natural Resources and Environment, Bangkok 10900, Thailand
  • 4 Department of Chemistry, Center of Excellence for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50300, Thailand

Abstract

Goniothalamus plants belonging to the family Annonaceae are found in Thailand and have been used as Thai traditional medicines. Members of this family are rich in a wide variety of biological active compounds including alkaloids, acetogenins and styryllactones. The present research described phytochemical study of the leaves and twigs of G. marcanii together with their cytotoxicity. The G. marcanii was selected and percolated with hexane, ethyl acetate and methanol. The extracts were purified and elucidated chemical structures. The constituents of ethyl acetate extract of G. marcanii have been investigated. We isolated and identified three derivative styryllactones e.g., 5-hydroxygoniothalamin (1), 5-acetylgoniothalamin (2) and goniopypyrone (3). The structures of these compounds were elucidated on the basis of spectroscopic evidence. Studies on ethyl acetate extract of G. marcanii have now resulted the isolation and structural characterization of three styryllactones. Their anticancer activities were evaluated using SRB assays. In this method, compound 1 and 2 showed potential activity in cell lines.

American Journal of Applied Sciences
Volume 10 No. 1, 2013, 112-116

DOI: https://doi.org/10.3844/ajassp.2013.112.116

Submitted On: 26 November 2012 Published On: 26 January 2013

How to Cite: Mahiwan, C., Buayairaksa, M., Nuntasaen, N., Meepowpan, P. & Pompimon, W. (2013). Potential Cancer Chemopreventive Activity of Styryllactones from Goniothalamus marcanii. American Journal of Applied Sciences, 10(1), 112-116. https://doi.org/10.3844/ajassp.2013.112.116

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Keywords

  • Goniothalamus marcanii
  • Goniothalamus
  • Styryllactone