Research Article Open Access

Bioactive Goniothalamin from Goniothalamus tapis with Cytotoxic Potential

Kallaya Sangrueng1, Saksri Sanyacharernkul2, Sirinapa Nantapap2, Narong Nantasaen3 and Wilart Pompimon4
  • 1 Phranakhon Rajabhat University, Thailand
  • 2 Chiang Mai University, Thailand
  • 3 Ministry of Natural Resources and Environment, Thailand
  • 4 Lampang Rajabhat University, Thailand


Goniothalamus (Annonaceae) is well known for the rich of styryllactone contents and these plants are famous for the potential to be applied as alternative biological activities. The chemical and biological investigations of Goniothalamus tapis is tested for anticancer activities. The research was processioned to extract, isolate, purify and elucidate structure from the leaves and twigs of G. tapis. The isolated compound was evaluated with cytotoxic activity. Goniothalamin was isolated from ethyl acetate extract of G. tapis and the spectroscopic techniques were used for structure elucidation. In addition, goniothalamin was the most powerful to cytotoxic activity which was the first reported for this specie. The goniothalamin was possessed a potent cytotoxicity. Therefore, it is possible to use this compound as a pharmacological agent.

American Journal of Applied Sciences
Volume 12 No. 9, 2015, 650-653


Submitted On: 9 June 2015 Published On: 4 October 2015

How to Cite: Sangrueng, K., Sanyacharernkul, S., Nantapap, S., Nantasaen, N. & Pompimon, W. (2015). Bioactive Goniothalamin from Goniothalamus tapis with Cytotoxic Potential. American Journal of Applied Sciences, 12(9), 650-653.

  • 4 Citations



  • Annonaceae
  • Goniothalamus tapis
  • Goniothalamin
  • Cytotoxicity