Research Article Open Access

Understand the Role of Natural Killer

Han Yuen Lam1, Swee Keong Yeap1, Noorjahan Banu Alitheen1, Wan Yong Ho1, Abdul Rahman Omar1, Khatijah Yusoff1, Abd Aziz Suraini2 and Huynh Ky3
  • 1 University Putra Malaysia, Malaysia
  • 2 University Putra Malaysia 43400 UPM, Malaysia
  • 3 Cantho University, Vietnam


Problem statement: Immunosuppression is a common approach for pathogens or cancer to escape from immune system of the infected host. Some of the antimicrobe or anticancer drugs may also weaken the body immune system. Among various types of immune cell, natural killer cells are the key component of the innate immunity which plays an important role in first line defense against cancer and microbe infections. Thus, understand the role of Natural killer cell can help to design a successful natural killer cell base therapy in cancer and infectious disease therapy. Approach: Natural killer cell unik activation/inhibition ligand, cytolytic granules and proinflammatory cytokiens offered a specific killing mechanism toward cancer or infected cell target. These specific activation can be achieved in the present of immunomodulator such as cytokines (IL-2 and IL-12) or mitogens (plant extract such as Rhaphidophora korthalsii methanol extract). Results: Key rule of Natural killer cell base immunotherapy is to maintain enough activated Natural killer cell number in the infected host. Conclusion/Recommendations: Future study should expand the clinical use of in vivo or ex-vivo Natural killer cell base therapy especially in cancer treatment.

American Journal of Immunology
Volume 6 No. 4, 2010, 54-61


Submitted On: 1 August 2011 Published On: 5 August 2011

How to Cite: Lam, H. Y., Yeap, S. K., Alitheen, N. B., Ho, W. Y., Omar, A. R., Yusoff, K., Suraini, A. A. & Ky, H. (2010). Understand the Role of Natural Killer. American Journal of Immunology, 6(4), 54-61.

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  • Peripheral blood mononuclear cell
  • Natural Killer (NK)
  • Caspase-Activated DNase (CAD)
  • immunological memory
  • Lymphokine Activated Killer (LAK)
  • Cytotoxic T Cells (CTL)
  • condition may happen