Research Article Open Access

Rat Model for Poly-Autoimmunity

Maria Staykova1
  • 1 The Australian National University, Australia

Abstract

Around 30% of the male PVG rats have very low testosterone levels. Upon immunisation with myelin basic protein in complete Freund’s adjuvant they develop experimental autoimmune encephalomyelitis and adjuvant arthritis. The androgen insensitive syndrome in these rats could be used in studies on poly-autoimmunity as well as in studies on variations in the sexual differentiation of brain and behavior.

American Journal of Immunology
Volume 8 No. 3, 2012, 84-87

DOI: https://doi.org/10.3844/ajisp.2012.84.87

Submitted On: 3 September 2012 Published On: 7 September 2012

How to Cite: Staykova, M. (2012). Rat Model for Poly-Autoimmunity. American Journal of Immunology, 8(3), 84-87. https://doi.org/10.3844/ajisp.2012.84.87

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Keywords

  • Male PVG Rat
  • Experimental Autoimmune Encephalomyelitis
  • Adjuvant Arthritis
  • Poly-Autoimmunity
  • Sexual Behavior