Research Article Open Access

Plasmodium Pre-Erythrocytic Stages: Biology, Whole Parasite Vaccines and Transgenic Models

Kota Arun Kumar1 and Satish Mishra2
  • 1 University of Hyderabad, India
  • 2 Johns Hopkins University, United States

Abstract

Malaria remains one of the world’s worst health problems, which causes 216 million new cases and approximately 655,000 deaths every year WHO World Malaria Report, 2011. Malaria transmission to the mammalian host is initiated through a mosquito bite that delivers sporozoites into the vertebrate host. The injected sporozoites are selectively targeted to liver which is the first obligatory step in infection thus making this stage an attractive target for both drug and vaccine development. Research using rodent models of malaria has greatly facilitated the understanding of several aspects of pre-erythrocytic parasite biology and immunology. However, translation of this knowledge to combat Plasmodium falciparum infections still offers several challenges. We highlight in this review some of the recent advances in the field of Plasmodium sporozoite and liver stage biology and in the generation of whole organism attenuated vaccines. We also comment on the application of transgenic models central to Circumsporozoite Protein (CSP) in understanding the mechanism of pre-erythrocytic immunity.

American Journal of Immunology
Volume 8 No. 3, 2012, 88-100

DOI: https://doi.org/10.3844/ajisp.2012.88.100

Submitted On: 26 December 2012 Published On: 13 September 2012

How to Cite: Kumar, K. A. & Mishra, S. (2012). Plasmodium Pre-Erythrocytic Stages: Biology, Whole Parasite Vaccines and Transgenic Models. American Journal of Immunology, 8(3), 88-100. https://doi.org/10.3844/ajisp.2012.88.100

  • 3,840 Views
  • 2,805 Downloads
  • 1 Citations

Download

Keywords

  • Plasmodium
  • Sporozoites
  • Circumsporozoite Protein
  • Liver Stages
  • Malaria Vaccine