Research Article Open Access

Effects of a Topical Composition of GABA and Microbial Chondroitin Sulfate on Mental Calmness and Brain Function

Marco Ruggiero1
  • 1 National Coalition of Independent Scholars. 125 Putney Rd Battleboro, VT 05301, United States


This article describes a novel topical composition constituted by Gamma-Aminobutyric Acid (GABA) and microbial chondroitin sulfate. This composition, formulated by the author and manufactured in a certified facility in the United States of America, exhibits potential for non-invasive intervention in anxiety management, sleep quality enhancement and promotion of brain-related functions like meditation and nonlocal consciousness. The core component comprises GABA, a key inhibitory neurotransmitter within the central nervous system, complexed with a suitable carrier molecule, microbial chondroitin sulfate. This complexation aims to enhance transdermal absorption and optimize the delivery of GABA to target tissues. The proposed mechanism of action involves modulation of GABAergic signal transduction pathways. Application of the topical composition allows GABA penetration into the skin and potentially deeper tissues, where it interacts with GABA receptors. This interaction leads to mental calmness and relaxation as assessed by electroencephalography. The influence of GABAergic signaling on brain circuits demonstrated in this article, when associated with meditation and nonlocal consciousness, suggests potential for the composition to support these practices. The advantage of such an approach consists in avoiding the potential systemic side effects associated with oral or injectable administration of GABA, anxiolytics, or hypnotics. Furthermore, the combination of GABA and microbial chondroitin sulfate may offer synergistic benefits, potentially enhancing the overall biological effects. In conclusion, this article presents a novel topical approach for managing anxiety, enhancing sleep quality and potentially facilitating meditation and nonlocal consciousness through the modulation of GABAergic signaling pathways. While further research is necessary, the potential for a non-invasive and potentially side-effect-free intervention in these areas is promising.

American Journal of Immunology
Volume 19 No. 1, 2024, 1-10


Submitted On: 17 January 2024 Published On: 8 March 2024

How to Cite: Ruggiero, M. (2024). Effects of a Topical Composition of GABA and Microbial Chondroitin Sulfate on Mental Calmness and Brain Function. American Journal of Immunology, 19(1), 1-10.

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  • Brain
  • Immune System
  • Gamma-Aminobutyric Acid GABA
  • Chondroitin Sulfate
  • Relaxation
  • Stress