Research Article Open Access

Anti-Ulcer (Ulcer-Preventive) Activity of Ficus arnottiana Miq. (Moraceae) Leaf Methanolic Extract

Marslin Gregory1, K. P. Vithalrao1, G. Franklin2 and V. Kalaichelavan1
  • 1 Annamalai University, India
  • 2 University of Minho, Portugal


Problem statement: In spite of being one of the well-known medicinal plants used in Indian traditional medicine to treat several ailments, studies pertaining to the pharmacological properties of Ficus arnottiana are very scarce. We studied the anti-ulcer activity and acute toxicity of Ficus arnottiana leaf methanolic extract for the first time. Approach: Freshly collected F. arnottiana leaves were dried, powdered and extracted in methanol. To study the anti-ulcer activity, Wistar rats were orally administered with different doses of the extract (0, 250 and 500 mg kg-1 body weight day-1) or with the reference drug omeprazole (8 mg kg-1) for 10 days. After induction of ulcer using 5 mL kg-1 ethanol, stomachs of these animals were analyzed for gastric volume, ulcer area and gross pathological changes. Results: Our results showed that F. arnottiana methanolic extract could prevent ulcer in rats in a dose-dependent manner. Histological studies revealed that the extract had muco-protective activity. The extract did not show any acute toxicity even at the dose of 5000 mg kg-1 indicating that the extract has no lethal effect. Preliminary phytochemical screening of this extract identified the presence of important secondary metabolites like flavonoids and tannins. Conclusion/Recommendations: From this study, it is clear that F. arnottiana leaf extract had significant anti-ulcer activity in animal models. It had muco-protective activity and gastric anti-secretary activity. The extract is non-toxic even at relatively high concentrations.

American Journal of Pharmacology and Toxicology
Volume 4 No. 3, 2009, 89-93


Submitted On: 23 May 2009 Published On: 30 September 2009

How to Cite: Gregory, M., Vithalrao, K. P., Franklin, G. & Kalaichelavan, V. (2009). Anti-Ulcer (Ulcer-Preventive) Activity of Ficus arnottiana Miq. (Moraceae) Leaf Methanolic Extract . American Journal of Pharmacology and Toxicology, 4(3), 89-93.

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  • Ficus arnottiana
  • flavonoids
  • gastric volume
  • ulcer area
  • omeprazole