Research Article Open Access

Evaluation of Antimalaria Activity and Acute Toxicity of Xetospongia sp

Syamsudin Abdillah1, Rahmatul Wahida Ahmad2, Yatnita Parama Cita3 and Noriah Mohd Noor2
  • 1 Pancasila University, Indonesia
  • 2 International Islamic University Malaysia, Malaysia
  • 3 School of Health Sciences, Indonesia

Abstract

We investigated the in vivo activity of extract of Xetospongia sp against Plasmodium berghei Strain ANKA and acute toxicity in mice. The ethanolic extracts of the Xetospongia sp (50-400 mg kg-1 day) were screened for blood schizonticidal against P. berghei strain ANKA in mice during early and established infections. Acute toxicity of extracts of Xetospongia sp at the dose 5000 mg kg-1 on mice administeredorally exhibited no toxicity, as evident in that fact that no histopathological changes were observed in some essential organs, such as liver, heart, digestive tract and kidney. The ethanolic extracts (50-400 mg kg day-1) exhibited a significant antimalarial activity both in the 4-day early infection test and in the established infection and they were found to be relatively safe up to a dosage of 5000 mg kg-1, with an LD50 value of >500 mg kg-1.

American Journal of Pharmacology and Toxicology
Volume 8 No. 2, 2013, 83-88

DOI: https://doi.org/10.3844/ajptsp.2013.83.88

Submitted On: 20 August 2013 Published On: 2 September 2013

How to Cite: Abdillah, S., Ahmad, R. W., Cita, Y. P. & Noor, N. M. (2013). Evaluation of Antimalaria Activity and Acute Toxicity of Xetospongia sp. American Journal of Pharmacology and Toxicology, 8(2), 83-88. https://doi.org/10.3844/ajptsp.2013.83.88

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Keywords

  • Xetospongia sp
  • Antimalarial Activity
  • Acute Toxicity