Research Article Open Access

Modulatory Effects of Bryophyllum Pinnatum Leaves Extract on Peroxidation Indices of CCl4 Induced-Hepatotoxicity in Wistar Albino Rats

Chioma Assumpta Anosike1, Sophia Uyo Mokwunye1, Victor Eshu Okpashi1 and Obiorah Abonyi1
  • 1 University of Nigeria, Nigeria

Abstract

This research investigated the modulatory effect of methanol extract of Bryophyllum pinnatum leaves on peroxidation indices of CCl4-induced hepatotoxicity. Thirty rats of average weight 150g divided into six groups of 5 rats each were used for the study. Group one (control) received water and paraffin for ten days. Group two (treatment control) received water only, group 3 (standard control), received a 100 mg/kg b.w of ascorbic acid, groups 4, 5 and 6 received 200, 400 and 600 mg/kg b.w of Bryophyllum pinnatum extract, respectively. Hepatotoxicity was induced by CCl4 administration in groups 2 to 6 on the 7th and 8th days. There was significant increase in the level of high density lipoprotein (HDL) and non-significant decreases in total cholesterol and triacylglycerol in the extract treated groups (4-6) compared to group two (CCl4 untreated). There was a significant increase in the level of low density lipoprotein (LDL) in the extract treated groups (4-6) compared to group one. Animals in groups 4-6 showed a significant decrease in MDA concentration compared to that of group one. Report from this study shows that Bryophyllum pinnatum extract has modulatory effect on the lipid profile of Wistar rats intoxicated with CCL4.

American Journal of Pharmacology and Toxicology
Volume 12 No. 3, 2017, 62-67

DOI: https://doi.org/10.3844/ajptsp.2017.62.67

Submitted On: 1 August 2017 Published On: 17 December 2017

How to Cite: Anosike, C. A., Mokwunye, S. U., Okpashi, V. E. & Abonyi, O. (2017). Modulatory Effects of Bryophyllum Pinnatum Leaves Extract on Peroxidation Indices of CCl4 Induced-Hepatotoxicity in Wistar Albino Rats. American Journal of Pharmacology and Toxicology, 12(3), 62-67. https://doi.org/10.3844/ajptsp.2017.62.67

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Keywords

  • Bryophyllum Pinnatum
  • Peroxidation Indices
  • Hepatotoxicity
  • Modulatory Effects
  • Carbon Tetrachloride