Obesity as a Predisposing Factor for Atherosclerosis

Abstract

Obesity stands as a pressing global health concern, associated with a myriad of threats to human well-being and longevity. Within the scope of this review, we zero in on how obesity impacts the onset of atherosclerosis, given its well-established link as a risk factor in its development. The progression of atherosclerosis is notably hastened by obesity, driven by a host of mechanisms including heightened blood pressure, elevated glucose levels, compromised lipid profiles and systemic inflammation. Of particular significance are the intricate cellular and molecular pathways that underpin the genesis of atherosclerosis. To shed light on this complex web, our endeavor has been to gather insights into the distinct roles played by diverse adipokines and lay down a structured framework for understanding their contributions in this context.