TY  - JOUR
AU  - Hamdan, Yousef 
AU  - Jiang, Xiangmei 
AU  - Huang, Kaixun 
AU  - Yu, Kaichao 
PY  - 2007
TI  - Preparation and Properties of Copolyanhydrides Based on 2-Hexadecylsuccinic Acid and Sebacic Acid
JF  - American Journal of Applied Sciences
VL  - 4
IS  - 3
DO  - 10.3844/ajassp.2007.128.132
UR  - https://thescipub.com/abstract/ajassp.2007.128.132
AB  - Poly(2-hexadecylsuccinic acid-sebacic acid) (P(HSA-SA)) copolymers have been prepared by melt polycondensation. The copolymers were characterized by FT-IR, 1HNMR, gel permeation chromatography (GPC), differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA). In vitro studies showed that all our prepared copolymers are degradable in phosphate buffer at 37°C. The release profiles of hydrophilic model drug, ciprofloxcin hydrochloride, from the copolymers, follow first order release kinetics. All the preliminary results suggested that the copolymer might be potentially used as drug delivery devices.