TY  - JOUR
AU  - Win, Yip-Foo 
AU  - Teoh, Siang-Guan 
AU  - Vikneswaran, M. R. 
AU  - Chan, Mun-Yee 
AU  - Ha, Sie-Tiong 
AU  - Ibrahim, Pazilah 
PY  - 2010
TI  - Synthesis and Characterization of Organotin(IV) Complexes Derived of 2-amino-5-nitrobenzoic Acid: In vitro Antibacterial Screening Activity
JF  - American Journal of Applied Sciences
VL  - 7
IS  - 7
DO  - 10.3844/ajassp.2010.886.891
UR  - https://thescipub.com/abstract/ajassp.2010.886.891
AB  - Problem statement: Tremendous studies have been carried out on organotin(IV) complexes derivatives of carboxylate anions. However, the synthesis and characterization as well as the in vitro antibacterial screening activity of organotin(IV) carboxylate derived of 2-amino-5-nitrobenzoic acid have not been carried out. Approach: Organotin(IV) carboxylate complexes derivative of 2-amino-5-nitrobenzoic acid, 2-NH2-5-NO2-C6H3COOH have been successfully synthesized. The acid and complexes obtained were characterized quantitatively using C, H, N and Sn elemental analysis as well as spectroscopic methods such as infrared (FTIR) and nuclear magnetic resonance (1H, 13C, 1H-13C HMQC and 119Sn NMR). Moreover, the complexes obtained were screened for their in vitro antibacterial screening activity. Results: Monomeric R2Sn (2-NH2-5-NO2-C6H3COO)2 (R = methyl 1, butyl 2) and dimeric {[(Bu2Sn(2-NH2-5-NO2-C6H3COO)]2O}2  3 as well as Ph3Sn(2-NH2-5-NO2-C6H3COO) 4 are obtained in solid state. Results of the infrared spectroscopy on the acid and complexes showed that the coordination took place via oxygen atoms from the carboxylate anions. Based on the 119Sn NMR solution study, the tin atom of both complexes 1 and 2 exhibit six-coordination respectively and complex 3 exhibits five- and six-coordination whereas the tin atom of complex 4 exhibits five-coordination. Conclusion: Pure complexes derived of 2-amino-5-nitrobenzoic acid have been successfully obtained. Triphenyltin(IV) are found to possess better  in vitro antibacterial screening activity on two gram-positive bacterial compared to the parent acid.