@article {10.3844/ajassp.2011.310.317,
article_type = {journal},
title = {Synthesis, Characterization and Biological Activities of Organotin (IV) Methylcyclohexyldithiocarbamate Compounds},
author = {Awang, Normah and Baba, Ibrahim and Yamin, Bohari M. and Othman, Mohd Sham and Kamaludin, Nurul Farahana},
volume = {8},
year = {2011},
month = {Apr},
pages = {310-317},
doi = {10.3844/ajassp.2011.310.317},
url = {https://thescipub.com/abstract/ajassp.2011.310.317},
abstract = {Problem statement: The growing interest in the chemistry of sulphur donor ligands are due
to their encouraging anticancer, antibacterial and antifungal activities as well as their widespread
industrial application. Dithiocarbamates belong to this class and much attention has been paid to them.
Approach: Novel organotin compounds with the molecular formula RmSn[S2CN(CH3)(C6H11)]4-m
(where m = 2, R = CH3, C2H5; m = 3, R = C6H5) have been synthesized using in situ method. These
compounds were characterized by elemental analysis, IR, 1H and 13C NMR spectroscopy. Results:
Elemental analysis revealed that all compounds were of good purity. Infrared spectra of the
compounds showed that the thioureide ν(C-N) band was in the region 1450-1500 cm−1. The unsplitting
band of ν(C-S) in the region 974-979 cm−1
indicated the bidentate nature of the chelated
dithiocarbamato legends. The 13C NMR chemical shift of the carbon atom in the N-CS2 group appeared
in the range of 196.29-199.82 ppm. Single crystal analysis from one of these compounds showed that the
chelating mode of the dithiocarbamate groups was isobidentate. These compounds have been screened
for antibacterial activity against four bacteria; Staphylococcus aureus, Salmonella typhimurium,
Pseudomonas aeruginosa and Bacillus subtilis. Only one of these compounds shows promising results
against S. aureus and S. typhi. Cytotoxicity screening on human leukemic promyelocyte HL-60 cells
found that two of these compounds were very active with CD50 values of 0.87 and 0.18 µg mL−1.
Conclusion: The studied compounds were found to have the potential in biological activity especially
in cytotoxicity where this possibly can be used for clinical trials after further research.},
journal = {American Journal of Applied Sciences},
publisher = {Science Publications}
}