@article {10.3844/ajbbsp.2010.264.267,
article_type = {journal},
title = {Anti β2-Glycoprotein I Antibodies in Women with Recurrent Spontaneous Abortion},
author = {Jahromi, Abdolreza Sotoodeh and Farjam, Mohammad Reza and Mogharrab, Farideh and Daryanavard, Ali and Madani, Abdolhossien and Hossienpour, Mahmoud and Manshoori, Gita and Yazdi, Mohammad Sadegh Gholvardi and Davoudi, Hossien and Montazerghaem, Hossein and Hassanlangi, Reza Safari},
volume = {6},
number = {4},
year = {2010},
month = {Dec},
pages = {264-267},
doi = {10.3844/ajbbsp.2010.264.267},
url = {https://thescipub.com/abstract/ajbbsp.2010.264.267},
abstract = {Problem statement: Antiphospholipid antibodies (aPL) are associated with repeated miscarriages and pregnancy complications, however their pathogenic mechanisms are still matter of research. Anti-β2 glycoprotein 1 (β2GPI) antibody is one of these aPL that its contribution to RSA risk remains poorly understood. There were not any data about role this auto-antibody in RSA in South of Iran. This study was conducted to assess Anti- β2GPI IgM and IgG as RSA risk factors for RSA in this area of Iran. Approach: This case-control study was carried out in gynecology special hospital of Hormozgan University of medical sciences, during 2004-2005. A number of 250 women with >3 consecutive idiopathic pregnancy losses as a case group and 200 age matched women with normal full term delivery and negative history of miscarriage as a controls were studied. All obtained sera from the case and the control groups were tested using an Enzyme Linked Immunosorbent Assay (ELISA) method for detection of anti-β2GPI IgM and IgG. Data was analyzed, using SAS 8 statistical software (chi square and t-test). Results: There were significant differences between the prevalence of positive anti-β2GPI IgM (p = 0.01) and IgG (p = 0.02) in the case group and the control group. A positive significant relationship was observed in the case group between number of abortion and seropositivity for anti-β2GPI IgG (p = 0.028, r = +0.181) and anti-β2GPI IgM (p = 0.0381, r = +0.014). Conclusion: This study showed anti-β2GPI antibodies are important causative agent for RSA in this area of Iran.},
journal = {American Journal of Biochemistry and Biotechnology},
publisher = {Science Publications}
}