@article {10.3844/ajbbsp.2022.184.194,
article_type = {journal},
title = {Role of the Wnt/β-Catenin Signaling Pathway in Reducing Lipogenesis of Obese Rats Under Hypoxic Exercise},
author = {Xu, Peiming and Sun, Zhiyuan and Tian, Xiaoyi and Yang, Yingjie and Wang, Qinglu and Tian, Xuewen},
volume = {18},
number = {2},
year = {2022},
month = {Jun},
pages = {184-194},
doi = {10.3844/ajbbsp.2022.184.194},
url = {https://thescipub.com/abstract/ajbbsp.2022.184.194},
abstract = {Hypoxic exercise exerts a significant effect on body weight loss and body fat reduction. Methods: In the present study, we constructed an obese rat model and divided rats into the following groups: Normoxic quiet (C), Hypoxic quiet (H), Normoxic Exercise (CE), and Hypoxic Exercise (HE). We employed isobaric tags for relative and absolute quantification (iTRAQ) using proteomic technology to screen the differentially expressed proteins in the four groups. Additionally, we used Reduced-Representation Bisulfite Sequencing (RRBS) to analyze high-throughput DNA methylation profiles in both HE and CE groups. Finally, we screened and analyzed the CpG islands and Differentially Methylated Regions (DMRs) of genes related to the Wnt/β-catenin-signaling pathway. Results: The mRNA levels of gene products related to the Wnt/β-catenin-signaling pathway (i.e., c-myc and β-catenin) were significantly augmented (P},
journal = {American Journal of Biochemistry and Biotechnology},
publisher = {Science Publications}
}