TY  - JOUR
AU  - Bakowski, Elcio 
AU  - Wey, Sérgio Barsantini 
AU  - Medeiros, Eduardo Alexandrino Servolo 
PY  - 2008
TI  - Risk Factors for Bacteremia and Predictors of Mortality of Patients with Bloodstream Infection with Methicillin-Resistant Staphylococcus aureus
JF  - American Journal of Infectious Diseases
VL  - 4
IS  - 4
DO  - 10.3844/ajidsp.2008.262.266
UR  - https://thescipub.com/abstract/ajidsp.2008.262.266
AB  - The objective of this study was to evaluate the incidence of infection and the risk factors
associated to bacteraemia and mortality due to Methicillin-Resistant Staphylococcus Aureus (MRSA).
This cohort study, conducted from August 2004 through November 2005, involved 60 consecutively
identified patients with bloodstream MRSA infection. The control group included 240 non-infected
patients, randomly selected and hospitalized on the day, or immediately after, results of blood culture
of case patients were available. A case-control (1:4) study was conducted for evaluation of risk factors
for bacteraemia and death. The incidence of infection was 1.99/1000 admissions. Mortality rates were
30% among patients and 5.38% among controls, with an attributed death rate of 24.6%. Multivariate
analysis indicated the following risk factors for bacteraemia: severity predictors McCabe = 1, ASA>2
or APACHE II>10 (OR: 4.1; 95% CI: 1.8 - 9.4) and use of central venous catheter (OR: 7.3; 95% CI:
2.4-22.2). University analysis showed as risk factors for mortality: age (OR: 1.08; 95% CI: 1.03-1.12),
severity predictors McCabe = 1, ASA > 2 or APACHE II > 10 (OR: 9.13; 95% CI: 2.57-32.35), use of
mechanical ventilation (OR: 10.32; 95% CI: 1.78-59.51) and use of corticoids (OR: 9.96; 95% CI:
2.69-36.78). Our results when investigating risk factors for bacteremia and mortality due to MRSA
showed moderate influence of control group selection, in comparison to studies in which methicillinsensitive
S. aureus infection is used as control.