TY  - JOUR
AU  - Hung, Nguyen Thanh 
AU  - Lan, Nguyen Trong 
AU  - Lin, Yee-Shin 
AU  - Lin, Chiou-Feng 
AU  - Lien, Le Bich 
AU  - Huang, Kao-Jean 
AU  - Yeh, Trai-Ming 
AU  - Ha, Do Quang 
AU  - Huong, Vu Thi Que 
AU  - Chen, Lien-Cheng 
AU  - My, Lam Thi 
AU  - Huang, Jyh-Hsiung 
AU  - Liu, Ching-Chuan 
AU  - Lei, Huan-Yao 
PY  - 2008
TI  - Anti-Platelet and Anti-Endothelial Cell Autoantibodies in Vietnamese Infants and Children with Dengue Hemorrhagic Fever
JF  - American Journal of Infectious Diseases
VL  - 4
IS  - 1
DO  - 10.3844/ajidsp.2008.41.49
UR  - https://thescipub.com/abstract/ajidsp.2008.41.49
AB  - Dengue hemorrhagic fever (DHF) is a serious public health problem. Increased vascular permeability and thrombocytopenia are the hallmarks of DHF. The mechanisms involved in DHF/Dengue shock syndrome (DSS) pathogenesis is not fully understood. This study gives evidence of the presence of antibodies which cross-reacted with platelets, and endothelial cells in the sera of Vietnamese infants and children with DHF/DSS. The anti-platelet, anti-endothelial cell IgM levels were higher in the sera of DHF/DSS infants and children, compared with controls. However, the levels of these autoantibodies were not correlated with the severity of DHF (non-shock DHF vs DSS). The antiplatelet, and anti-endothelial cell autoantibodies may play a role in the pathogenesis of DHF/DSS in infants and children with predominantly primary, and secondary dengue infections, respectively. The epitopes shared by surface molecules of platelets and endothelial cells and dengue virus antigens need to be identified and avoided in designing the safe candidate vaccines.