TY  - JOUR
AU  - Huang, Kao-Jean 
AU  - Cheng, Yu-Tien 
AU  - Lin, Yee-Shin 
AU  - Huang, Jyh-Hsiung 
AU  - Liu, Hsiao-Sheng 
AU  - Yeh, Trai-Ming 
AU  - Liu, Ching-Chuan 
AU  - Lei, Huan-Yao 
PY  - 2008
TI  - Anti-Prm Antibody as an Autoantibody in Dengue Virus Infection
JF  - American Journal of Infectious Diseases
VL  - 4
IS  - 1
DO  - 10.3844/ajidsp.2008.60.68
UR  - https://thescipub.com/abstract/ajidsp.2008.60.68
AB  - We have reported that anti-prM antibody is an enhancing antibody that enhances DV infection of non-Fc receptor bearing cells by dual specificity. We identified the epitope recognized by this anti-prM antibody, M3, which is located at the a.a.53-67of the prM protein nearby the prM/M cleavage junction and these anti-M3 antibodies could be detected in dengue patients sera. Surprisingly, this anti-prM antibody not only recognizes the prM protein of dengue virions, but also cross-reacts with epithelial cells, endothelial cells as well as T cells. The binding of anti-prM antibody to endothelial cells was dose-dependent and could be blocked by M3 peptides. Human M3-specific antibodies from dengue patient sera were demonstrated to be able to bind to endothelial cells and mediate ADE infection on K562 cells. Furthermore, the anti-prM antibody will mediate the antibody - dependent cell phagocytosis, leading to the similar severe form of DHF/DSS. In conclusion, anti-prM antibody plays two roles in the pathogenesis of dengue virus infection: to be an enhancing antibody and an autoantibody as well.