TY  - JOUR
AU  - Ravada, Suryachandra Rao 
AU  - Emani, Lakshma Reddy 
AU  - Garaga, Machi Raju 
AU  - Meka, Bharani 
AU  - Golakoti, Trimurtulu 
PY  - 2009
TI  - Synthesis of Coenzyme Q10
JF  - American Journal of Infectious Diseases
VL  - 5
IS  - 2
DO  - 10.3844/ajidsp.2009.83.89
UR  - https://thescipub.com/abstract/ajidsp.2009.83.89
AB  - Problem statement: CoQ10 is a key compound in ATP synthesis having 
wide number of health application especially for treating humans suffering from 
pathophysiological condition. The CoQ10 presently available in the market is solely 
derived from fermentation process. A commercially viable synthetic process is 
yet to be realized. Approach: The researchers described a new 
synthetic route for the preparation of CoQ10 (1). This new process utilized inexpensive 
isoprenol as a precursor for the synthesis of an early intermediate with a single 
isoprene unit. Another key step was the selective oxidation of trans methyl of 
isoprene unit as a prelude to the expansion of the side chain to decaprenyl group 
using solanesol. Results: Prenylation of 2, 3-dimethoxy-5-methylhydroquinone 
using isoprenol in presence of a Lewis acid, followed by selective oxidation of 
trans methyl group of isoprenyl side chain and subsequent allylic bromination 
yielded a bromide precursor (7). The p-toluenesulfination of the bromide followed 
by coupling with solanesyl bromide and de-p-toluenesulfination yielded dimethyl 
derivative of the CoQ10-quinol. Finally CAN oxidation of dimethyl quinol followed 
by purification yielded CoQ10 in 13% overall yield. Conclusion: 
The present process achieved CoQ10 starting from a relatively inexpensive precursor. 
Further improvement in the coupling reaction between 8 and solanesyl bromide may 
lead to a better and viable synthetic process.