TY  - JOUR
AU  - Avelar Pires, Carla Andrea 
AU  - Weba Costa, Eline Pinheiro 
AU  - Duarte Costa, Marcus Vinicius 
AU  - Pitman Machado, Adriana Kamilly Leitão 
AU  - de Lima Dias, Aline 
AU  - Amin, Gabriela Athayde 
AU  - de Lemos, Manuela Nascimento 
AU  - da Silva, Alison Ramos 
AU  - Neves Noronha, Marcos Antonio 
AU  - Xavier, Marilia Brasil 
PY  - 2019
TI  - Endoscopic Changes of Nasal Mucosa in Patients with Leprosy
JF  - American Journal of Infectious Diseases
VL  - 15
IS  - 2
DO  - 10.3844/ajidsp.2019.53.61
UR  - https://thescipub.com/abstract/ajidsp.2019.53.61
AB  - Leprosy is a chronic granulomatous disease, affecting the skin and Schwann cells of peripheral nerves. In most leprosy cases, the nasal mucosa is affected. We aimed to describe the clinical changes in nasal mucosa using nasal endoscopy, in patients with leprosy attending a dermatology service in an endemic region and compare this changes with those founds in non-leprosy patients nasal mucosa. This cross-sectional study examined and compared 16 leprosy patients and 16 non-leprosy patients. Nasal endoscopy was conducted in both groups to determine differences between the two groups and analysis was applied to evaluate factors related to changes in the nasal mucosa. A larger number of changes in the nasal mucosa was observed in multibacillary patients (75%); infiltration, lepromas and hematic crusts were the changes that were most commonly observed. There was a larger proportion of men (68.8%) diagnosed as having leprosy; they demonstrated a 23-fold increase of nasal mucosa involvement compared to women. There was no positive correlation between nasal symptoms and changes observed in the nasal mucosa. Therefore, it is important to perform an otorhinolaryngological examination and, more importantly, an endoscopic examination of the nasal mucosa, regardless of the presence or absence of symptoms or the clinical presentation of patients with leprosy.