TY  - JOUR
AU  - de Almeida-Leite, Rodrigo Moisés 
AU  - Bonatti, Tais Rondello 
AU  - Ponzoni, Carolina Rodrigues 
AU  - Korndorfer, Ana Cristina da Cunha 
AU  - da Silva, Solange Bifani Tavares 
PY  - 2020
TI  - Is Hydroxychloroquine a Safe and Effective Choice for Covid-19 Prophylaxis
JF  - American Journal of Infectious Diseases
VL  - 16
IS  - 3
DO  - 10.3844/ajidsp.2020.118.119
UR  - https://thescipub.com/abstract/ajidsp.2020.118.119
AB  - The authors speculate about the possibility of Hydroxychloroquine as Covid-19 Phrophylaxis in the dose of 400 mg per week. The authors compared the experience of Malaria phrophylaxis in this dose, with acceptable safety profile. Also, we compared in vitro susceptibility of SARS-Cov-2 with that of Plasmodium falciparum. This agent show significant higher potency for the first. Also, the extended Half-life (40-50 days) make it an acceptable choice for prophylaxis. We also cite Brazilian experience with Chloroquinated Salt in the 1950s, its efficacy and feasibility. Lastly, we suggest that clinical trials should be conducted test this hypothesis.