@article {10.3844/ajidsp.2022.1.8,
article_type = {journal},
title = {Characteristics and Incidence of Candidemia in Hospitalized Coronavirus 2019 (COVID-19) Patients},
author = {Boachie, Naana A and Johnston, Jackie P. and Philip, Simi A. and Sullivan, Kaede V. and Heaney, Maria},
volume = {18},
number = {1},
year = {2022},
month = {Jan},
pages = {1-8},
doi = {10.3844/ajidsp.2022.1.8},
url = {https://thescipub.com/abstract/ajidsp.2022.1.8},
abstract = {Management of Coronavirus 2019 (COVID-19) with high-dose corticosteroids and interleukin-2 inhibitors has potential benefits, but is associated with immunosuppression and risk of secondary infections. This single-center, retrospective, cohort study evaluated the incidence of candidemia and associated risk factors in hospitalized COVID-19 patients. Twenty-three patients developed candidemia and were matched to 77 non-candidemic COVID-19 controls. The primary outcome was incidence of candidemia. Secondary outcomes included time to first positive fungal blood culture and antifungal initiation, antifungal treatment duration, fungal isolate identification, candidemia risk factors, in-hospital mortality, Intensive Care Unit (ICU) and hospital Length of Stay (LOS) and mechanical ventilation duration. Candidemia incidence was 0.7% (23/3101). Mean time from hospital admission to first positive fungal blood culture was 26.2±14.3 days, with systemic antifungal therapy initiated in 19 patients; seven started antifungal therapy the same day cultures were drawn and 12 within 24 h of preliminary culture results positive for yeast. The remaining four patients expired prior to culture results. Mean duration of antifungal therapy was 9.7±6.6 days. Candida albicans was the most frequently identified isolate. Candidemic patients were more likely to be admitted to the ICU, receive high-dose corticosteroid, renal replacement therapy, mechanical ventilation, central line, tocilizumab and broad-spectrum antimicrobials. They also had higher mortality (82% vs. 22%, p},
journal = {American Journal of Infectious Diseases},
publisher = {Science Publications}
}