@article {10.3844/ajisp.2006.61.63,
article_type = {journal},
title = {Risk of Second Non Breast Malignancies (SNBM) in Relation to Brca1 And Brca2 Mutation Status Following Breast-Conserving Surgery and Radiotherapy},
author = {Kirova, Youlia M. and Fourquet, Alain and Savignoni, Alexia and Sigal-Zafrani, Brigitte},
volume = {2},
year = {2006},
month = {Sep},
pages = {61-63},
doi = {10.3844/ajisp.2006.61.63},
url = {https://thescipub.com/abstract/ajisp.2006.61.63},
abstract = {Women from hereditary breast cancer families with BRCA1/2 germline mutation are at increased risk for contralateral breast cancer (BC) and for ovarian cancer (OC). It is less clear whether mutation status influences the rate of SNBM other than OC. In addition, little is known on the risk of OC in individuals from hereditary BC families without identified BRCA mutation. Our purpose was to answer to these two questions. We retrospectively analysed a cohort of women with small cancers treated with breast conserving surgery and radiotherapy at our Institut from 1981 to 2000. The studied population was matched using strict criteria. BRCA1/2 carriers had more SNBM than the French women population (FWP) (SIR=1099.2 [354.3-2565.4], p},
journal = {American Journal of Immunology},
publisher = {Science Publications}
}