@article {10.3844/ajisp.2006.88.96,
article_type = {journal},
title = {The Serological Gastric Biopsy: A Non-endoscopical/Histopathologic Diagnostic Approach in Management of the Dyspeptic Patients},
author = {Mahmoud, R. A.K. and Morcos, H. H. and Hegazi, A. A. and Abo Seif, M. A. and El-Hadidy, K. S.},
volume = {2},
year = {2006},
month = {Dec},
pages = {88-96},
doi = {10.3844/ajisp.2006.88.96},
url = {https://thescipub.com/abstract/ajisp.2006.88.96},
abstract = {Objective: To asses the sensitivity, specificity and the predictive value of a 'gastropanel' blood test, including serum pepsinogen I (S-PGI) and amidated gastrin-17 (S-G-17) in the diagnosis of atrophic gastritis most probably due to helicobacter pylori (Hp) and to compare the results of serology with the endoscopic/histopathologic findings as a gold standard diagnostic tool. This study comprised 86 dyspeptic outpatients who underwent a diagnostic gastroscopy with multiple biopsies from the antrum and corpus for histopathologic examination. Histopathologically, the series of cases included 46 patients diagnosed as having atrophic gastritis. Twenty five had an antral atrophy, 6 had corpus atrophy and 15 patients had an atrophic gastritis in both the antrum and corpus (multifocal atrophic gastritis) MAG. The remaining 40 cases were considered as controls, 32 had a non-atrophic gastritis (NAG) and both the antrum and corpus were normal and healthy in 8 subjects. The fasting levels of S-PGI and antibodies to Hp IgG-antibodies (S-HpAb) and postprandial amidated S-G-17 (S-G-17prand) were measured 20 min after a protein-rich drink and were determined using enzyme immunoassay (EIA) methods. The serologic and morphologic results were compared with estimating the sensitivity, specificity, positive and negative predictive (PPV and NPV) and accuracy values of the tests (S-G-17 and S-PGI). Mean values of both S-G-17prand and S-PGI decreased with increasing grade of antral and corpus atrophy, respectively. A low S-PGI (},
journal = {American Journal of Immunology},
publisher = {Science Publications}
}