TY  - JOUR
AU  - Sujatha, M. 
AU  - Dhasarathan, P. 
AU  - Karthick, B. 
PY  - 2010
TI  - Antibiotic Susceptibility and Immunomodulatory Potential of Chosen Bacterial Pathogens
JF  - American Journal of Immunology
VL  - 6
IS  - 2
DO  - 10.3844/ajisp.2010.15.19
UR  - https://thescipub.com/abstract/ajisp.2010.15.19
AB  - Problem statement: Antibiotic susceptibility is still the best way for bacterial pathogen
escape mechanism against immunity. Approach: In the present investigation, bacterial pathogens like
Staphylococcus aureus, Escherichia coli, Aeromonas hydrophila, Klebsiella and Pseudomonas
aeruginosa were used to screen antibiotic susceptibility and immunomodulatory potential. Results: All
the test pathogens were sensitive to all the test antibiotics 11±2 mm) except penicillin. The conditions for the preparation of antigens of intact natural composition and conformation from pathogens (whole cell and heat killed), were determined using Swiss albino mice (Balb/C) as experimental species. Immunomodulatory potential of test pathogens were screened using animal model. Test pathogen decreases the body weight comparing that of normal mice, some notable changes were also noted in activity, growth, water consumption, feed consumption. Antibody titre level in animal serum decreased upto 50% in whole cell pathogen and heat killed pathogen treated animals. Conclusion: The five pathogens administered animals, decrement in B-lymphocyte was much pronounced in Pseudomonas aeruginosa followed by Escherichia coli, Staphylococcus aureus, Klebsiella sp., Aeromonas hydrophila in the 5 week. Pathogen treated mice showed an IgG suppressive effect. It is found to be suppressive to T cell production, so induction in cell mediated immunity has confirmed pathogenic potential of test pathogens. All these test pathogenic strains were remarkably suppressing immune system of pathogen exposed animals.