@article {10.3844/ajisp.2010.25.28,
article_type = {journal},
title = {Antiviral and Quantitative Structure Activity Relationship Study for Dihydropyridones Derived from Curcumin},
author = {Saeed, Bahjat A. and Saour, Kawkab Y. and Elias, Rita S. and Al-Masoudi, Najim A.},
volume = {6},
year = {2010},
month = {Jun},
pages = {25-28},
doi = {10.3844/ajisp.2010.25.28},
url = {https://thescipub.com/abstract/ajisp.2010.25.28},
abstract = {Problem statement: Pyridones are known to have variety of biological activities like
antitumor, antibacterial, anti-inflammatory and antimalarial activities. This study presents antiviral
evaluation of dihydropyridones derived from curcumin, as well as curcumin for comparison.
Approach: The compounds evaluated for their in vitro antiviral activities against the viruses: HIV-1,
Bovin viral Diarrhea, Yellow Fever, Reovirus 1, Herpesvirus 1, Vaccinia, Vescular Stomatitis,
Coxackie virus B2, Poliovirus 1 and Respiratory Syncytial viruses by using Microculture Tetrazolium
assay (MTT) method. The method was based on the metabolic reduction of 3-(4,5-dimethylthiazol-2-
yl)-2,5-diphenyltetrazolium bromide. Results: Antiviral biological activities represented as CC50 were
within the range >100-26 for BHK-21, while they were within the range >90-≥13 against Respiratory
Syncytial Virus when represented as EC50 for example. Both CC50 and EC50 values were found to
increase with increasing chain length of the substituent on the nitrogen atom. Conclusion: The in vitro
antiviral activities of the tested dihydropyridones can be enhanced by increasing chain length of the
substituent on the nitrogen atom.},
journal = {American Journal of Immunology},
publisher = {Science Publications}
}