TY  - JOUR
AU  - Liu, Yuan 
AU  - Gan, Lu 
AU  - Shi, Guixiu 
PY  - 2012
TI  - Role of Galphaq Containing Protein in Immune Regulation
JF  - American Journal of Immunology
VL  - 8
IS  - 4
DO  - 10.3844/ajisp.2012.154.165
UR  - https://thescipub.com/abstract/ajisp.2012.154.165
AB  - G proteins, one of the most important transmembrane signal transducers, contain four subfamilies. Gαq is the α subunit of Gq protein subfamily. The Gαq containing protein initially attracted attention for its physiological significance is in cardiovascular system. In recent years, its role in immune regulation has been indicated. Studies domenstrated that Gαq plays crucial role in regulating both innate and adaptive immune cells function and it is involved in the development of autoimmune disease. In this review, we summarized recent data in the role of Gαq containing protein in regulating immune cells function and the possible mechanisms.