@article {10.3844/ajisp.2012.44.51,
article_type = {journal},
title = {Microbial Translocation and B Cell Dysfunction in Human Immunodeficiency Virus Disease},
author = {Jiang, Wei},
volume = {8},
year = {2012},
month = {Jun},
pages = {44-51},
doi = {10.3844/ajisp.2012.44.51},
url = {https://thescipub.com/abstract/ajisp.2012.44.51},
abstract = {The gut mucosal barrier disrupted in HIV disease, resulting in increased systemic exposure to microbial products such as Lipo Polys Accharide (LPS). The association of enhanced microbial translocation and B cell dysfunction in HIV disease is not fully understood. High dose and short term exposure of microbial Toll-Like Receptor (TLR) agonists were used as vaccine adjuvants, however, low dose and long term exposure of TLR agonists could be harmful. The characteristics of B cell dysfunction in HIV disease included B cell, especially memory B cell depletion, enhanced levels of autoimmune antibodies and impaired vaccine or antigen responsiveness. This review discusses and explores the possibility of the effect of microbial translocation on memory B cell depletion and impaired vaccine responses in HIV infection. By determining the mechanisms of B cell depletion and perturbations in HIV disease, it may be possible to design interventions that can improve immune responses to vaccines, reduce selected opportunistic infections and perhaps slow disease progression.},
journal = {American Journal of Immunology},
publisher = {Science Publications}
}