@article {10.3844/ajisp.2014.183.188,
article_type = {journal},
title = {Immunomodulatory and Antioxidant Properties of Kaurenoic Acid on Macrophages of BALB/c in Vitro},
author = {Macri, Juliana Aparecida and Silva, Suelen Santos da and Miranda, Milena Menegazzo and Kawakami, Natalia Yoshie and Hayashida, Thiago Hideki and Madeira, Tiago Bervelieri and Nixdorf, Suzana Lucy and Junior, Vinicius Ricardo Acquaro and Ambrósio, Sérgio Ricardo and Jr, Waldiceu Aparecido Verri and Cecchini, Rubens and Conchon-Costa, Ivete and Arakawa, Nilton Syogo and Pavanelli, Wander Rogério},
volume = {10},
year = {2015},
month = {Feb},
pages = {183-188},
doi = {10.3844/ajisp.2014.183.188},
url = {https://thescipub.com/abstract/ajisp.2014.183.188},
abstract = {Kaurenoic acid has been displaying anti-inflammatory effect described in different models. However, the per se immunomodulatory effects of kaurenoic acid remain to be investigated. Thus, the immunomodulatory and antioxidant effects of kaurenoic acid were investigated in vitro on peritoneal macrophages from BALB/c mice. Kaurenoic acid induced per se the production of pro-inflammatory cytokines such as TNFα, IL-1β and IFN-γ while also increased the levels of IL-10. There was also reduction of NO production and induction of anti-oxidant profile. Therefore, in addition to inhibiting inflammation, kaurenoic acid presents immunomodulatory effects per se.},
journal = {American Journal of Immunology},
publisher = {Science Publications}
}