TY  - JOUR
AU  - Macri, Juliana Aparecida 
AU  - Silva, Suelen Santos da 
AU  - Miranda, Milena Menegazzo 
AU  - Kawakami, Natalia Yoshie 
AU  - Hayashida, Thiago Hideki 
AU  - Madeira, Tiago Bervelieri 
AU  - Nixdorf, Suzana Lucy 
AU  - Junior, Vinicius Ricardo Acquaro 
AU  - Ambrósio, Sérgio Ricardo 
AU  - Jr, Waldiceu Aparecido Verri 
AU  - Cecchini, Rubens 
AU  - Conchon-Costa, Ivete 
AU  - Arakawa, Nilton Syogo 
AU  - Pavanelli, Wander Rogério 
PY  - 2015
TI  - Immunomodulatory and Antioxidant Properties of Kaurenoic Acid on Macrophages of BALB/c in Vitro
JF  - American Journal of Immunology
VL  - 10
IS  - 4
DO  - 10.3844/ajisp.2014.183.188
UR  - https://thescipub.com/abstract/ajisp.2014.183.188
AB  - Kaurenoic acid has been displaying anti-inflammatory effect described in different models. However, the per se immunomodulatory effects of kaurenoic acid remain to be investigated. Thus, the immunomodulatory and antioxidant effects of kaurenoic acid were investigated in vitro on peritoneal macrophages from BALB/c mice. Kaurenoic acid induced per se the production of pro-inflammatory cytokines such as TNFα, IL-1β and IFN-γ while also increased the levels of IL-10. There was also reduction of NO production and induction of anti-oxidant profile. Therefore, in addition to inhibiting inflammation, kaurenoic acid presents immunomodulatory effects per se.