@article {10.3844/ajisp.2014.46.55,
article_type = {journal},
title = {ASSOCIATION OF TESTOSTERONE AND CHOLESTEROL LEVEL IN MODULATION OF IMMUNITY AND SEVERITY OF DISEASE IN VISCERAL LEISHMANIASIS PATIENTS-A PRELIMINARY STUDY},
author = {Pandey, Krishna and Singh, Dharmendra and Bimal, Sanjiva and Murti, Krishna and Das, Pradeep},
volume = {10},
year = {2014},
month = {Mar},
pages = {46-55},
doi = {10.3844/ajisp.2014.46.55},
url = {https://thescipub.com/abstract/ajisp.2014.46.55},
abstract = {Males are more prone to Visceral Leishmaniasis (VL) as compared to females. The role of androgens in host defence against Leishmania and other pathogens is of considerable interest. This study was aimed to understand a baseline mechanistic understanding of the pathogenesis of visceral leishmaniasis with respect to testosterone. We examined the relationship between serum testosterone and cholesterol levels, antigen induced Interleukin-10 (IL-10) and Interferon-gamma (IFN-γ) and production by Peripheral Blood Mono Nuclear Cells (PBMCs) and parasite burden as determined by microscopic examination on male patients (n = 18) with VL and gender-and age-matched controls (n = 10). Testosterone plasma levels were found to be up regulated in VL patients as compared to healthy controls. In severely infected patients, the mean testosterone concentration was observed to be increased compared with other VL patients (p},
journal = {American Journal of Immunology},
publisher = {Science Publications}
}