@article {10.3844/ajisp.2016.20.28,
article_type = {journal},
title = {A Novel Glucan-Sulforaphane Combination Stimulates Immune Response to Influenza in Mouse Model},
author = {Vaclav, Vetvicka and Jana, Vetvickova},
volume = {12},
year = {2016},
month = {Aug},
pages = {20-28},
doi = {10.3844/ajisp.2016.20.28},
url = {https://thescipub.com/abstract/ajisp.2016.20.28},
abstract = {Influenza remains a serious health problem and causes approximately 500,000 deaths world-wide. With current available treatments offering neither dependable protection nor a rapid cure, many have focused their attention to alternative treatments. The aim of this study was to evaluate the possible effect of a novel maitake glucan-sulforaphane combination on immune response against influenza challenge in mice. We evaluated the effects of a glucan-sulforaphane combination on basic immune reactions, virus titre and overall survival after influenza infection. Results: We found 2 weeks supplementation with this glucan-sulforaphane combination significantly improved immunosuppression caused by the viral infection. Based on these results, we conclude that the significant immunostimulation caused by this combination helps to overcome virus-dependent suppression of defense reactions and that addition of sulforaphane to glucan can improve already established biological effects of glucan.},
journal = {American Journal of Immunology},
publisher = {Science Publications}
}