@article {10.3844/ajptsp.2009.80.84,
article_type = {journal},
title = {Cytoprotective Effect of UlGen, a Polyherbal Formulation against Physical and Chemical Factor Induced Gastric Ulcers in Wister Albino Rats },
author = {Muralidhar, T. S. and Balaji, Anna and Bandopadhyay, Chinmay and Shantha, S. L.},
volume = {4},
year = {2009},
month = {Sep},
pages = {80-84},
doi = {10.3844/ajptsp.2009.80.84},
url = {https://thescipub.com/abstract/ajptsp.2009.80.84},
abstract = {Problem statement: UlGen, a Polyherbal formulation, was investigated for its possible Ulcero-protective activity in ulcerogen and Cold-restraint stress induced Wister rats (Rattus rattus). Oral administration of UlGen, at a dose of 800 mg kg-1 significantly protected the onset of cold-resistance stress induced ulcerations. Approach: It significantly inhibited gastric ulceration induced by alcohol and aspirin. Control group: Alcohol 80% induced ulcer was 42.00±2.30 and in UlGen treated rats showed 10.00±1.62. Using alcian blue stain to study the mucus secretion by mucosal cells carried out histological examination of gastric glandular mucosa. Results: The volume and acidity of gastric juice in pyloric-ligated rats was reduced in treated rats. Gastric volume (mL 100 g-1) in control rats showed 4.12±0.32 and in UlGen treated rats showed 2.50±0.20. Conclusion: UlGen, Cytoprotective effect may be due to the enhancement of defensive mechanism through an improvement of gastric cytoprotection as well as acid inhibition.},
journal = {American Journal of Pharmacology and Toxicology},
publisher = {Science Publications}
}