TY - JOUR AU - Edem, D. O. AU - Usoh, I. F. PY - 2009 TI - Biochemical Changes in Wistar Rats on Oral Doses of Mistletoe (Loranthus micranthus) JF - American Journal of Pharmacology and Toxicology VL - 4 IS - 3 DO - 10.3844/ajptsp.2009.94.97 UR - https://thescipub.com/abstract/ajptsp.2009.94.97 AB - Problem statement: To evaluate the effects of the water extract of the leaves of mistletoe (Loranthus micranthus) (traditionally used antidiabetic and antihypertensive) in male albino Wistar rats. Approach: The animals were divided into 4 groups (n = 6). Water extract of L. micranthus leaves was administered in graded doses of 0, 275, 551 and 827 mg kg-1 body weight (wt) of experimental animals for 21days. Blood samples were collected by cardiac puncture. The serum harvested was analyzed for some biochemical parameters, using assay kits. Results: There were no significant changes (p>0.05) in the levels of cholesterol, bilirubin, glucose, protein, urea, alkaline phosphatase and Aspartate Transaminase (AST). Alanine Transaminase (ALT) activities of the groups rats given 551 and 827 mg kg-1 body weight extracts (15.96 and 14.24 U L-1 respectively) showed significant decreases (p