@article {10.3844/ajptsp.2010.103.108,
article_type = {journal},
title = {Cardioprotective Effect of Lagenaria siceraria (Molina) Standley (Cucurbitaceae) Fruit Juice on Doxorubicin Induced Cardiotoxicity in Rats},
author = {Fard, M. Hassanpour and Naseh, G. and Bodhankar, S. L. and Dikshit, M.},
volume = {5},
year = {2010},
month = {Jun},
pages = {103-108},
doi = {10.3844/ajptsp.2010.103.108},
url = {https://thescipub.com/abstract/ajptsp.2010.103.108},
abstract = {Problem statement: The cardio toxicity of Doxorubicin (Dox) has limited its use as an
anticancer drug. The aim of present study was to investigate the cardio protective effect of
Lagenaria Siceraria (Cucurbitaceous) Fruit Juice (LSFJ) against the cardio toxicity of Dox in rats.
Approach: Male wistar rats (250-300 g) were randomly divided into four groups. Group I- was
control, Group II- Dox (10 mg kg-1), groups III and IV- Dox + LSFJ (5 and 10 mL kg-1 for 18 days).
Dox (10 mg kg-1 iv) was administered in group II, III and IV on day 16. After anesthetizing the
animals on the 18th day, Electrocardiogram (ECG) was recorded and blood was investigated for
Creatine Kinase-MB is enzyme (CK-MB), Lactate Dehydrogenase (LDH) and Aspartate
Aminotransferase (AST) while determination of Superoxide Dismutase (SOD), Reduced Glutathione
(GSH), Lipid Per Oxidation (LPO) and histopathology was carried out for heart. Results: Group 3 and
4 of animals showed decreased QT interval (p},
journal = {American Journal of Pharmacology and Toxicology},
publisher = {Science Publications}
}