@article {10.3844/ajptsp.2010.145.151,
article_type = {journal},
title = {Acute and Sub-Acute Toxicological Assessment of Aqueous Leaf Extract of Bryophyllum Pinnatum (Lam.) in Sprague-Dawley Rats},
author = {Ozolua, Raymond Iduojemu and Idogun, Sylvester Eshiotseme and Tafamel, Glory Eshiagiamhe},
volume = {5},
year = {2010},
month = {Sep},
pages = {145-151},
doi = {10.3844/ajptsp.2010.145.151},
url = {https://thescipub.com/abstract/ajptsp.2010.145.151},
abstract = {Problem statement: The aqueous leaf extract of Bryophyllum pinnatum has been reported
to possess antihypertensive, antiinflammatory, antimicrobial, antidiabetic and antiulcer properties
among others. Being readily available and easy to cultivate, the use of the plant in herbal medicine has
been on the increase. Although there are few toxicological reports on the extract, these have not been
sufficiently extensive. We therefore designed this study in order to evaluate more extensively the acute
and sub-acute toxicity of the extract in rats. Approach: Oral and intraperitoneal (i.p) LD50 experiments
were conducted on Sprague-Dawley rats. Other rats were given daily doses of 2 g kg-1 body weight
(p.o) × 35 days at the end of which kidneys, hearts, spleen and blood/sera were obtained for weight,
haematological and biochemical analyses. Results: While there was no death at a maximum acute dose
of 5 g kg-1 body weight by the oral route, the intraperitoneal LD50 was 1.8 g kg-1 body weight. Subacute
treatment did not significantly alter animal weights, organ-to-body weight ratios, fluid intake,
hematological indices and the levels of AST, ALP and albumin. ALT level was significantly reduced
(p},
journal = {American Journal of Pharmacology and Toxicology},
publisher = {Science Publications}
}