@article {10.3844/ajptsp.2011.124.129,
article_type = {journal},
title = {Prenatal Exposure to Chronic Ethanol on N Methyl D Aspartate Receptor Distribution},
author = {Taherianfard, M. and Geramizadeh, B. and Evazi, E. and Sharifi, M.},
volume = {6},
year = {2012},
month = {Feb},
pages = {124-129},
doi = {10.3844/ajptsp.2011.124.129},
url = {https://thescipub.com/abstract/ajptsp.2011.124.129},
abstract = {Problem statement: Effect of chronic exposure to ethanol on NR1 subunit of the NMDA receptor distribution in chick embryo brain chronic ethanol intake leads to the development of dependence on and tolerance to ethanol in both human and animals. The glutamate system plays a major role in mediating ethanol effects on brain and behavior. The aim of the present study was to investigate whether chronic ethanol exposure altered NR1 subunit of N-Methyl-D-Aspartate (NMDA) receptor distribution in the developing chick brain on 10 and 15th day of egg incubation. Approach: Forty fertilized eggs divided in 2 groups, control and chronic. In the chronic group the eggs were chronically exposed to ethanol 10% during 15 day of embryonic period. Immunohistochemical procedure was used for NR1 subunit of NMDA receptor distribution determination. Image analyzer program were used for color analyzing of immunohistochemistry slides. Data were analyzed statistically by Student T test. The level of significance was assumed to be (p},
journal = {American Journal of Pharmacology and Toxicology},
publisher = {Science Publications}
}