@article {10.3844/ajptsp.2012.1.7,
article_type = {journal},
title = {Electroanalytical Determination of Doripenem using a Screen-Printed Electrode},
author = {Al-Shaalan, Nora H.},
volume = {7},
year = {2012},
month = {Feb},
pages = {1-7},
doi = {10.3844/ajptsp.2012.1.7},
url = {https://thescipub.com/abstract/ajptsp.2012.1.7},
abstract = {Problem statement: The performance characteristics of Sensitive Screen-Printed (SPE) and Carbon Paste (CPE) electrodes were investigated for the Determination of Doripenem (DP) in pure, pharmaceutical preparations and biological fluids. Approach: The proposed electrodes is characterized in terms of plasticizer type, response time, pH and temperature. Results: The two electrodes showed nearly Nernstian behaviours over the concentration range of 2×10−4-5×10−2 mol/l of the drug with slopes of 58 and 57 mV/decade for SPE and CPE electrodes, respectively. The electrodes exhibited good selectivity for DP with respect to a large number of inorganic cations and organic substances present in the biological fluids. The method was precise, as shown by the mean recoveries of 99.49-100 and 98.49-99.49% with mean relative standard deviations 0.38-0.78 and 0.60-0.90% for SPE and CPE electrodes, respectively. Conclusion: Doripenem was determined successfully in pure solutions, in vials or in biological fluids using the standard addition and potentiometric titration methods.},
journal = {American Journal of Pharmacology and Toxicology},
publisher = {Science Publications}
}