@article {10.3844/ajptsp.2016.26.31,
article_type = {journal},
title = {Effects of Artemisinin-Based Combination Therapies on Lipids and Hepatorenal Circulating Indices in Guinea Pigs},
author = {Mankwe, Abaram Chesa and Aprioku, Jonah Sydney and Obianime, Atuboyedia Wolfe},
volume = {11},
year = {2017},
month = {Apr},
pages = {26-31},
doi = {10.3844/ajptsp.2016.26.31},
url = {https://thescipub.com/abstract/ajptsp.2016.26.31},
abstract = {Artemisinin-based Combination Therapies (ACTs) are employed as first-line agents in malaria chemotherapy. In many malaria endemic areas, ACTs are frequently abused partly due to resistance, poor drug control and inadequate health facilities. This study investigated the effects of prolong administration of Artesunate-Sulfadoxine-Pyrimethamine (ATS-SP), Artesunate-Amodiaquine (ATS-Amod) and Artemether-Lumefantrine (ATM-Lum) on plasma levels of biochemical parameters (AST, ALT, ALP, urea and creatinine) and lipids in guinea pigs. Adult guinea pigs were administered standard (NTD) or Double Therapeutic Dose (DTD) equivalents of ATS-SP, ATS-Amod or ATM-Lum for 14 days. Some other animals received similar drug treatments but were allowed to recover for 14 days. Control group was given vehicle. ATS-Amod caused significant (p},
journal = {American Journal of Pharmacology and Toxicology},
publisher = {Science Publications}
}